The Valencian Research Institute for Artificial Intelligence (VRAIN) is a University Research Institute of the Universitat Politècnica de València, established by the Valencian Government through Decree 78/2021. With more than 176 researchers organised into eight research groups, the institute is one of Spain's largest dedicated AI research centres.

VRAIN's research spans nine areas of artificial intelligence — from natural language processing and machine learning to intelligent agents, computational logic, and software production methods — applied across sectors including health, industry, privacy and security, and environmental sustainability. The institute maintains a balance between fundamental and applied research, with sustained emphasis on doctoral training and technology transfer. A defining aspect of its research agenda is Trustworthy, Ethical, and Responsible AI: the development of systems that are accountable, explainable, and aligned with European values and societal needs.

VRAIN's technology transfer activity includes 24 software solutions and patents, alongside 35 specialised AI services available to industry and public organisations. The institute maintains contracts with companies at local, national, and international level.

The research groups that constitute VRAIN have been active in AI research since the early 1990s. Initially established in April 2019, the institute incorporated the Research Centre on Software Production Methods (PROS) in 2020 and received official recognition as a University Research Institute through Decree 78/2021, the highest research classification within the Spanish university system.

At the international level, VRAIN is an active member of CAIRNE (Confederation of Laboratories for Artificial Intelligence Research in Europe) and participates in EFFRA, RENIC, BDVA, AIOTI, NESSI, and Inndromeda.