At VRAIN, research in software production methods focuses on model-driven engineering, conceptual modelling, and Computer-Aided Method Engineering (CAME) — approaches that raise the level of abstraction in software development and enable the systematic construction of tailored production methods.

Tools developed in this area include MOSKitt4ME, a CAME environment for the construction of software production methods adapted to specific organisational contexts, and MATE, a model-based automation engine that interprets high-level model specifications at runtime to automate interaction patterns without code generation. Work also covers GREAT Process Modeller for business process reengineering and conceptual modelling programming (CMP) techniques, which allow domain experts to specify systems at a higher level of abstraction without direct low-level implementation. G-MAC is a conceptual model-based information system developed to manage and analyse clinical data for retina-macula pathology, demonstrating the application of model-driven methods to precision medicine.